A gene product can be annotated to zero or more terms from each ontology. Annotations represent the normal functions of gene products. Biological Process: the pathways and larger processes to which that gene product’s activity contributes. Cellular Component: where the gene products are active. Molecular Function: the molecular activities of individual gene products. Semantics of a GO annotationĪssociations of gene products to GO terms are statements that describe The GO evidence codes describe the type of evidence and reflect how far removed the annotated assertion is from direct experimental evidence, and whether this evidence was reviewed by an expert biocurator. In GO, the supporting evidence is presented in the form of a GO Evidence Codes and either a published reference or description of the methodology used to create the annotation. All GO annotations are ultimately supported by the scientific literature, either directly or indirectly. Gene product (may be a protein, RNA, etc.)ĭifferent pieces of knowledge regarding gene function may be established to different degrees, which is why each GO annotation always refers to the evidence upon which it is based. Although there are additional components a curator can use to indicate more information, including qualifiers and annotation extensions, at the very minimum an annotation consists of: There are four pieces of information that uniquely identify a GO annotation. Hence, GO annotations capture statements about how a gene functions at the molecular level, where in the cell it functions, and what biological processes (pathways, programs) it helps to carry out. Together, these statements comprise a “snapshot” of current biological knowledge. GO annotations are created by associating a gene or gene product with a GO term. If you're doing this for a class, you should get specific guidelines from your instructor.A GO annotation is a statement about the function of a particular gene. Your annotated bibliography may include some of these, all of these, or even others. How does it help shape your argument? How can you use this source in your research project? 
Once you've summarized and assessed a source, ask yourself how it fits into your research. Is it a useful source? How does it compare with other soruces in your biliography? What is the goal of this source? After summarizing a source, it may be helpful to evaluate it. Who wrote the document? When and where was the document written? What are the main arguments? What topics are covered? The length of your annotations will determine how detailed your summary is. Some annotations merely summarize the source. LIST OF ANNOTATIONS FULL
The annotated bibliography looks like a References page but includes an annotation after each full citation.Īnnotated bibliographies can be part of a larger research project, or can be a stand-alone report in itself.ĭepending on your project or the assignment, your annotations may do one or more of the following: Therefore, an annotated bibliography includes a summary and/or critical evaluation of each of the sources. An annotation is a summary and/or evaluation.
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